RenardV1, Main, Exploration, bibRecord, 001485

Identification of fox rabies by a monoclonal antibody directed against nucleocapsid of a street rabies virus.

Identifieur interne : 001485 ( Main/Exploration ); précédent : 001484; suivant : 001486

Identification of fox rabies by a monoclonal antibody directed against nucleocapsid of a street rabies virus.

Auteurs : J U Umoh [Nigeria] ; J H Cox ; L G Schneider ; S. Meyer

Source :

Zentralblatt fur Veterinarmedizin. Reihe B. Journal of veterinary medicine. Series B [ 0514-7166 ] ; 1990.

RBID : pubmed:2363325

English descriptors

KwdEn :
- Animals, Antibodies, Monoclonal (immunology), Capsid (immunology), Dogs, Foxes, Hybridomas, Mice, Mice, Inbred BALB C, Rabies (diagnosis), Rabies (veterinary), Rabies virus (immunology), Viral Core Proteins (immunology).
MESH :
- chemical , immunology : Antibodies, Monoclonal, Viral Core Proteins.
- diagnosis : Rabies.
- immunology : Capsid, Rabies virus.
- veterinary : Rabies.
- Animals, Dogs, Foxes, Hybridomas, Mice, Mice, Inbred BALB C.

Abstract

Hybridomas were prepared by fusion of spleen cells from BALB/c mice immunized with dog rabies isolates from Nigeria with P3x63Ag8 myeloma cells. More than 69 hybridomas secreted antinucleocapsid (antiNC) antibodies when tested with homologous viruses by indirect immunofluorescence. One hybridoma (Z144-88) was found which secreted antiNC antibody that reacted negatively with fox rabies isolates from the Federal Republic of Germany, Switzerland and France and with rabies-related viruses and European bat isolates. It reacted positively with other strains/isolates of rabies virus. It is possible to use this antiNC monoclonal antibody (mab) for the investigation of fox rabies outbreaks in Europe.

PubMed: 2363325

Affiliations:

Nigeria

Le document en format XML

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<author><name sortKey="Umoh, J U" sort="Umoh, J U" uniqKey="Umoh J" first="J U" last="Umoh">J U Umoh</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Veterinary Public Health and Preventive Medicine, Ahmadu Bello University, Zaria, Nigeria.</nlm:affiliation>
<country xml:lang="fr">Nigeria</country>
<wicri:regionArea>Department of Veterinary Public Health and Preventive Medicine, Ahmadu Bello University, Zaria</wicri:regionArea>
<wicri:noRegion>Zaria</wicri:noRegion>
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<author><name sortKey="Cox, J H" sort="Cox, J H" uniqKey="Cox J" first="J H" last="Cox">J H Cox</name>
</author>
<author><name sortKey="Schneider, L G" sort="Schneider, L G" uniqKey="Schneider L" first="L G" last="Schneider">L G Schneider</name>
</author>
<author><name sortKey="Meyer, S" sort="Meyer, S" uniqKey="Meyer S" first="S" last="Meyer">S. Meyer</name>
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<affiliation wicri:level="1"><nlm:affiliation>Department of Veterinary Public Health and Preventive Medicine, Ahmadu Bello University, Zaria, Nigeria.</nlm:affiliation>
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<author><name sortKey="Meyer, S" sort="Meyer, S" uniqKey="Meyer S" first="S" last="Meyer">S. Meyer</name>
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<series><title level="j">Zentralblatt fur Veterinarmedizin. Reihe B. Journal of veterinary medicine. Series B</title>
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<term>Foxes</term>
<term>Hybridomas</term>
<term>Mice</term>
<term>Mice, Inbred BALB C</term>
<term>Rabies (diagnosis)</term>
<term>Rabies (veterinary)</term>
<term>Rabies virus (immunology)</term>
<term>Viral Core Proteins (immunology)</term>
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<keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antibodies, Monoclonal</term>
<term>Viral Core Proteins</term>
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<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Rabies</term>
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<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Capsid</term>
<term>Rabies virus</term>
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<keywords scheme="MESH" qualifier="veterinary" xml:lang="en"><term>Rabies</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Dogs</term>
<term>Foxes</term>
<term>Hybridomas</term>
<term>Mice</term>
<term>Mice, Inbred BALB C</term>
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<front><div type="abstract" xml:lang="en">Hybridomas were prepared by fusion of spleen cells from BALB/c mice immunized with dog rabies isolates from Nigeria with P3x63Ag8 myeloma cells. More than 69 hybridomas secreted antinucleocapsid (antiNC) antibodies when tested with homologous viruses by indirect immunofluorescence. One hybridoma (Z144-88) was found which secreted antiNC antibody that reacted negatively with fox rabies isolates from the Federal Republic of Germany, Switzerland and France and with rabies-related viruses and European bat isolates. It reacted positively with other strains/isolates of rabies virus. It is possible to use this antiNC monoclonal antibody (mab) for the investigation of fox rabies outbreaks in Europe.</div>
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<name sortKey="Schneider, L G" sort="Schneider, L G" uniqKey="Schneider L" first="L G" last="Schneider">L G Schneider</name>
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Identification of fox rabies by a monoclonal antibody directed against nucleocapsid of a street rabies virus.

Identification of fox rabies by a monoclonal antibody directed against nucleocapsid of a street rabies virus.

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

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